Misopates orontium L. is traditionally used as diuretic, in liver disorders and also in treatment of ulcer. The objective of present study to evaluate anthelmintic, insecticidal and anti-ulcer potential of M. orontium. Albendazole (20mg/ml) was used as standard drug in anthelmintic activity. Permethrin (239.5μg/cm²) was used as standard insecticidal drug. While standard drugs used for anti-ulcer activity were ranitidine (50mg/kg), omeprazole (20mg/kg) and sucralfate (100mg/kg). In anthelmintic activity ethyl acetate and n- butanol fraction showed time of paralysis (59min), (57min) and death time (107min), (114min) respectively. No extract showed any significant insecticidal activity. Ulcer indices, percentage ulcer inhibition, gastric volume, pH, mucous and protein contents were assessed in ethanol induced ulcer model in rats. Chloroform extract of M. orontium significantly reduced gastric lesion 39.84% at 50mg/kg when compared to ranitidine (54.2%), omeprazole 20mg/kg (69.5%) and sucralfate 100mg/kg (53.6%). Gastric volume and total acidity decreased (1.87±0.2) (45.5±5.9) in chloroform treated group. While pH, mucous and protein content increased in comparison to ethanol treated group (5.1±0.3), (478.3±12.7), (26.1±4.1) and (2.4±0.1), (371.8±10.2), (16.2±3.2) respectively. Chloroform treated group all values are close relevant to standard drug treated groups. So it was concluded that chloroform extract showed more safe result as compared to other extracts.