Indigenous plants such as lemongrass and celery are rich sources of nutrients. There is a need to test their efficacy for ameliorating nephrotoxicity. Plant-derived drugs have emerged as alternative medicine. Previous studies have focused only on the formulation of detoxifying drinks but its in vivo studies were not performed. The present research was conducted to formulate and evaluate the nutritional composition and antioxidant potential of detoxifying drink variants and to assess their ameliorative effect on the renal toxicity induced by carbon tetrachloride (CCl₄) at 0.5ml/kg/day i.p in Wistar albino rats. Different detoxifying drink variantswere prepared by adding 0.5%, 1.0% and 1.5% of lemongrass powder (LG5, LG10 and LG15) and celery powder (CL5, CL10 and CL15) respectively to the standard drink SD. These additions resulted in a significant increase (p≤0.05) in all the nutritional parameters. In vivodata revealed that CCl₄ induced toxicity by increasing malondialdehyde (MDA) (6.87nmoles/ ml RBC lysate), decreased glutathione concentration (3.44µmole/ml RBC lysate) and attenuated antioxidant enzymes activity (U/mg protein) of SOD (0.82), GPx (5.83) and CAT (1.66). Detoxifying drinks significantly (p≤0.05) corrected urea, uric acid and creatinine levels in plasma. Group VI and VIII receiving LG15 and CL15 variants of detoxifying drink restored the enzymatic (SOD, GPx and CAT) activity (p≤0.05) and non-enzymatic parameters (GSH) and attenuated the lipid peroxidation in erythrocyte lysate. The detoxifying drink variant with 1.5% celery powder was equivalent to silymarin (herbal medicine) in protecting the kidney against CCL₄-induced toxicity.