Article Abstract

Volume 30, No. (2), 2020 (April)
MECHANISMS FOR SALMONELLA INFECTION AND POTENTIAL MANAGEMENT OPTIONS IN CHICKEN
M. Mkangara1, 2,*, R. Mwakapuja4, J. Chilongola3, P. Ndakidemi1, E. Mbega1 and M. Chacha1

1School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, P. O. Box 447, Arusha, Tanzania.
2Department of Science and Laboratory Technology, Dar es Salaam Institute of Technology, P.O. Box 2958, Dar es Salaam, Tanzania.
3Department of Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, P.O Box 2240, Moshi, Kilimanjaro, Tanzania
4Tanzania Veterinary Laboratory Agency, P.O. Box 9254, Dar es Salaam, Tanzania

Corresponding Author: mkangaram@yahoo.com
Page Number(s): 259-279
Published Online First: March 02, 2020
Publication Date: March 02, 2020
ABSTRACT

Salmonella enterica is the largest species in genus Salmonella with its serovars responsible for infection in chickens and other warm-blooded hosts. After oral ingestion, Salmonella penetrates the mucosal layer of the gastrointestinal tract (GIT). It then provokes gastroenteritis and systemic infection to chickens of all ages depending on the serovar involved. The paper explains about Salmonella infection via Type Three Secretion System (TTSS) encoded Pathogenicity Islands (PIs) and how the bacterium survives the acidic environment of GIT.  It also explains the roles of TTSS-1 and TTSS-2 in translocation of effectors that interfere with host proteins and later internalisation of Salmonella in Salmonella-containing vacuole (SCV). Other virulence factors such as plasmid, biofilm and lipopolysaccharides are highlighted, and their importance in inducing pathogenicity to host was also included in the paper. Therefore, several factors are geared toward survival, infection, and replication of Salmonella in the host cells. Hence, this article explains the mechanisms of Salmonella infection in chicken, its persistence in different environments and the approaches in controlling chicken salmonellosis.

Keywords: Salmonella, Type three Secretion System, Pathogenicity Islands, Chicken, Infection

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Journal Impact Factor: 0.5 | (JCR Year: 2025) | Cite Score: 1.3

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Print ISSN: 1018-7081

Electronic ISSN: 2309-8694

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