Canola meal (CM) is used in all types of poultry feeds, however, because of its relatively low energy; its use in high energy broiler diets is restricted. No study has been conducted to evaluate the nutritional composition of CM derived from an Egyptian variety (Serw 4) grown in Egypt for poultry diets. The present study focused on the nutritional evaluation of Egyptian CM (ECM) compared with soybean meal (SBM). ECM contained lower crude protein (35.98 vs. 50.92%); more ether extract (EE) (10.35 vs. 1.69%), crude fiber (12.58 vs. 3.60), calcium (0.53 vs. 0.32%) and total phosphorus (1.16 vs. 0.73%) on dry matter basis. ECM contained more inhibitor contents like phytic acid (2.13 vs. 1.29%) as compared to SBM whereas as it had 22.47 µmol/gm glucosinolates while it was not determined for SBM. Compared with SBM, as fed basis ECM contained total essential amino acids (20.44 vs. 19.66%); lower essential amino acid index (51.32 vs. 54.55%). The first, second and third limiting amino acids of ECM were methionine, phenyl alanine and isoleucine, while those of SBM were valine, methionine and cysteine, respectively. The biological evaluation of ECM and SBM was investigated with force-fed adult cockerels assay. Comparable with SBM, ECM had a lower apparent and true metabolizable energy than that of SBM (1.75 vs. 2.28 Kcal/g) and (2.39 vs. 3.12 Kcal/g), respectively. The calculated protein replacement value of ECM from SBM in poultry diets was 92.22%. Compared with SBM, ECM had nearly similar true amino acids availability mean (109.56 vs. 109.06) and similar TAAA of most AA; therefore, it could be a good alternative protein source for SBM in poultry diets. Generally, the presence of these essential nutrients implies that CM could be utilized as a safe protein in poultry diets with no detrimental effect on growth performance.