The process of regenerating organs that have been lost or damaged is fascinating hence it involves several cellular activities that come together to build a new structure. All creatures can regenerate to some extent; however, some have the astonishing ability of regeneration, while others have a limited capability and lose it with maturity. Having regenerative powers in adults is an argument in support of the hypothesis that development continues throughout an animal's life span. There are numerous physiological and pathological processes in which matrix metalloproteases (MMPs) play a fundamental regulatory part in synthesizing, remodeling, and destroying extracellular matrix (ECM) components. Catalytic and hemopexin domains are found at the C-terminal end of these proteins, as well as signaling peptides and propertied, which all include zinc ion binding sites. Numerous cell types may secrete or localize MMPs to their membranes in order to generate them. Enzymes such as MMPs are critical for reshaping the extracellular matrix by destroying specific components and encouraging the growth and differentiation of cells along the progression of apoptosis and angiogenesis. While in healthy mature tissue, they are unnoticeable until there is an abnormality, such as an accident, illness, or pregnancy. The present study aims to comprehend the function of matrix metalloproteinases (MMPs) in the regeneration of body organs and tissues in aquatic organisms, emphasizing the regulatory function of MMPs in the synthesis, remodeling, and degradation of extracellular matrix (ECM) components that are essential for cellular processes like growth, differentiation, and apoptosis. The review highlights recent discoveries that shed light on the ways in which MMPs aid in the regeneration of aquatic organisms after injuries or abnormalities.