Abomasal displacement is an important metabolic disorder that primarily affects exotic breeds of high-yielding dairy cows worldwide, causing significant economic losses to dairy herds. Indeed, the etiology and pathogenesis of bovine left displacement abomasum remain unclear. Therefore, this study was aimed to investigate the effect of left omentopexy among dairy cows on normal body parameters. Twenty-six cows were allocated into two groups: Control group-A (n=13) and Treatment group-B (n=13). LDA was confirmed by clinical assessment and ultrasonography and then surgically treated. Blood samples from both groups were collected on days 0, 7, 14, 21, and 28, respectively. Serum electrolyte profiles were evaluated by photometry, while the serum concentration of some biochemical parameters was evaluated by ELISA. The results indicated that serum levels of sodium, and potassium on days 0 to 14, while calcium, and chlorides on days 0 to 21 were lower (P=0.00) which increased to normal post-operatively in group-B than in group-A. Serum levels of blood urea nitrogen (P=0.00) on days 0 to 7; creatinine, Alanine aminotransferase (P=0.00) on days 0 to 21; aspartate aminotransferase, total protein, and globulin (P=0.00) on days 0 to 14 in group-B significantly increased (P<0.01) then it gradually decreased to normal (P>0.05) post-operatively compared with group-A. Serum levels of glucose, cholesterol, and triglycerides on days 0 to 14, while albumin (P=0.00) on days 0 to 21, significantly decreased (P<0.01) then gradually increased to normal (P>0.05) post-operatively in group-B than in group-A. The rectal temperature, pulse rate, and respiration rate of group-B increased (P=0.00) on days 0 to 7, then gradually decreased to normal (P>0.05) post-operatively than in group-A. The ruminal movement (P=0.00) on day 0 and the body condition score (P=0.00) on days 0 to 21 in group-B decreased (P<0.05) pre-operatively, then gradually increased to normal (P>0.05) post-operatively. In conclusion, LDA is associated with biochemical, physiological, and electrolyte profile changes that are rectified through surgical correction.