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Volume 28, No. (2), 2018 (April)

ACUTE DERMAL AND OCULAR IRRITATION TESTING OF GRAPE FRUIT SEED EXTRACT IN NEW ZEALAND WHITE RABBITS

Jae Young Kim, Jae-Suk Choi

Jae Young Kim1, and Jae-Suk Choi2*

1 Swine Science and Technology Center, Gyeongnam National University of Science and Technology, Jinju, Gyeongnam, 52725, Republic of Korea
2 Division of Bio-industry, College of Medical and Life Sciences, Silla University, 140, Baegyang-daero 700 beon-gil, Sasang-gu, Busan, 46958, Republic of Korea
Corresponding Author: jsc1008@silla.ac.kr
Page Number(s): 485-490
Published Online First: April 01, 2018
Publication Date: April 01, 2018

ABSTRACT

We investigated the acute dermal and ocular irritation potentials of grapefruit seed extract (GSE) in New Zealand white rabbits. In the dermal irritation test, erythema, eschar, and edema formation were observed after 24 h of GSE treatment, and the skin returned to normal after 72 h. The dermal primary irritation index of GSE was 0.25; therefore, it was classified as a mild irritant. In the ocular irritation test, there were no clinical signs related to the application of GSE; therefore, it was classified as a non-irritant according to the Draize scoring system. These results suggest that GSE is mildly or not irritating to the skin and eye, indicating that it can be used in cosmetic and pharmaceutical applications with no serious toxic effects at moderate doses.
Keywords: Grapefruit seed extract (GSE), Dermal irritation test, Ocular irritation test
Open Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).
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