The present study has been designed to evaluate proportional morbidity rate(PMR) along with comparative evaluation study between different diagnostic tools (viz., urinalysis, radiography, hyperkalemia, clinical signs and ultrasonography for Pandora Box Syndrome (PBS).A total of PMR among PBS cases was estimated to be 8.7%. For diagnostic test evaluation, all respective tests were performed according to the defined procedures. To this end,total of 208 diseased and 98 apparently healthy felines were tested by taking urinalysis as gold standard. All tests but serum cortisol level (80.303; 70.70-89.89%) showed 100 percent specificity. Serum cortisol was found to be significantly more sensitive (P<0.05) than ultrasonography, clinical signs, hyperkalemia, and radiography with highest negative predictive value (NPV)as 58.2, respectively. On comparing apparently healthy felines (n = 98) with diseased (n = 208;affected with PBS in the past or at present), highestagreement 0.812 (0.70-0.92%) was found between clinical signs and ultrasonography, while lowest agreement was seen between ultrasonography and hyperkalemia (0.449; 0.35-0.54%).In conclusion,PMR values show more about specialty as well as interests of clinicians rather than the incidence of disease in that population.