J. Xu, A. Zhou, Z. Wang and D. Ai
Chengdu Vocational College of Agricultural Science and Technology, Chengdu 611130, P.R. China *Key Laboratory for Animal Disease –Resistance Nutrition of China Ministry of Education, Ya’an, Sichuan 625014, China
Antigen protein contained in soybeans are the major cause of allergic reaction in young animals. In this study, glycinin and β-conglycinin were purified material and experimentally tested at concentration of 0.1, 5, and 10 mg/ml for their effects on integrity and immune responses of mouse intestinal epithelial cells. At 5 mg/ml or above, glycinin and β-conglycinin undermined the integrity of intestinal epithelial cells, inhibited epithelial cell proliferation, and significantly increase the levels of LDH and GOT released to the culture medium. The administration of glycinin and β-conglycinin also significantly promoted the secretion of inflammatory cytokines (IL-2, IL-6, IL-8), a key feature in allergic reactions.
Impact Score: 0.65; h Index:51
SJR: 0.20
Web of Science (SCIE): Q3
SCOPUS (Q3)
Journal Impact Factor (JIF): 0.6; JCR 2025 ; Five Year JIF: 0.7
HEC Category: W
Print ISSN: 1018-7081
Electronic ISSN: 2309-8694
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