COMBINATION EFFECTS OF Β-GLUCAN ORIGINATED FROM AUREOBASIDIUM AND PLATYCODIN ON THE OBESE DB/DB MOUSE
Jae-Suk Choi1#, Joo Wan Kim2#, Go-Woon Jung2, Dong-Chan Park2, Hyung-Rae Cho2, Sae Kwang Ku3*and Jae-Hak Sohn1**
1Division of Bioindustry, College of Medical and Life Sciences, Silla University, 140 Baegyang-daero, 700 beon-gil, Sasang-gu, Busan 617-736, Republic of Korea; 2Glucan corp. #305 Marine Bio-Industry Development Center, Hoenggye-ri 27, Ilgwang-myeon, Gijan-gun, Busan 619-912, Republic of Korea; 3Aribio Inc. Byeoksan Digital Valley, Suite 1004, Mullae-dong 5ga 9, Yeongdeungpo-gu, Seoul, 150-095, Korea; 4Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, 290 Yugok-dong, Gyeongsan-si, Gyeongsanbuk-do 712-715, Republic of Korea
**Corresponding author E-mail: firstname.lastname@example.org, *Co-corresponding author E-mail: email@example.com
#JSC and JWK contributed equally.
To find out the fittest composition, the anti-obesity effects of 11 types of the β-glucan compositions and platycodin (PLAT) (MPP) were observed in the obese db/db mouse at 200mg/kg-dosing levels with β-glucan or PLAT single formula, respectively. Test materials were administered orally once a day for 28 days. Each of seven mice per group was selected using blood glucose levels and body weight, and the changes in the body weight, epididymal fat weights, serum adiponectin and leptin levels, adipose adiponectin contents and liver triglyceride contents were monitored. The weights of epididymal fats, serum leptin levels and liver triglyceride contents in db/db control were significantly (p<0.01) increased compared to that of db/m with significant (p<0.01) decrease in serum adiponectin levels and adipose adiponectin contents. However, these obese changes were dramatically decreased after β-glucan single, PLAT single and some MPP-dosing and the changes related to the obese showed decreased trends along increasing the β-glucan composition. Synergic anti-obesity effects were restricted to the MPP 1:1 formulation compared to those of single formulas, respectively. The synergic anti-obesity effects detected in MPP 1:1 formulation were considered as results of the similar anti-obesity mechanisms of β-glucan and PLAT that inhibit the intestinal absorption of fats.
Keywords: β-Glucan, Platycodin, db/db mouse, obesity, adipokine, composition.