HAEMATOLOGICAL AND BIOCHEMICAL RISK FACTORS OF PARTURIENT HAEMOGLOBINURIA IN BUFFALOES
A. Mahmood, M. A. Khan, M. Younus*, M. A. Khan**, A. Ahad***, M. Ahmad****, H. J. Iqbal****, Z. Fatima**** and M. Anees***
Department of Epidemiology and Public Health, *Department of Pathology, **Department of Clinical Medicine and Surgery, ****Department of Parasitology and ***Department of Microbiology, Faculty of Veterinary Science, UVAS, Lahore
Corresponding author e-mail: malikaltafmahmood @ yahoo.com
ABSTRACT
A case-control epidemiological study was carried out to estimate the haematological and serum biochemical risk factors associated with parturient haemoglobinuria on 30 haemoglobinuric and 60 apparently healthy buffaloes selected from district Chakwal during December, 2010 and January, 2011. Non coagulated and coagulated blood samples were collected and tested for various haematological and biochemical parameters. Significantly (P<0.05) decreased total erythrocyte count (3.58±1.03×106/µl), haemoglobin concentration (6.90±1.39g/dl), haematocrit (19.26±4.28%), serum inorganic phosphorous (2.67±0.79mg/dl) and selenium (15.77±4.95µg/dl) whereas significantly (P<0.05) increased mean corpuscular volume (60.72±8.49fl), mean corpuscular haemoglobin (21.46±2.52pg), erythrocyte sedimentation rate (129.20±21.25mm/1st hour) and serum molybdenum (115.33±30.08µg/dl) were recorded in haemoglobinuric buffaloes with an odds ratio of 26, 17.81, 28.95, 7.50, 21, 12.25, 26 and 11 respectively. Non significant (P>0.05) difference was recorded between haemoglobinuric and healthy buffaloes with respect to mean corpuscular haemoglobin concentration and serum copper level with an odds ratio of 0.50 and 0.87 respectively. Hienz bodies were not detected on stained blood smears of haemoglobinuric as well as healthy buffaloes. It was concluded that low red cell count, haemoglobin concentration, haematocrit, serum inorganic phosphorous and selenium whereas; increased mean corpuscular volume, mean corpuscular haemoglobin and serum molybdenum content are potential risk factors associated with parturient haemoglobinuria.
Key words: haemoglobinuria, risk factors, hypophosphataemia, haemolytic anaemia, haemolytic syndrome
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