RT Journal T1 DEVELOPMENT OF NOVEL TOTAL INTRAVENOUS ANESTHESIA PROTOCOL USING CONSTANT RATE INFUSION IN GOATS DURING PAIN MANAGEMENT A1 M. Asif A1 M. A. Khan A1 H. Akbar A1 M. O. Omer JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 32 IS 2 SP 370 OP 382 YR 2022 FD 2022/03/15 DO DOI https://doi.org/10.36899/JAPS.2022.2.0434 AB

The study was aimed to develop a suitable total intravenous anesthesia protocol by comparative efficacy of three different combinations of detomidine, midazolam, propofol and ketamine in goats undergoing rumenotomy. In total, 18 female goats were divided into 3 treatment groups A, B and C comprising 6 animals each. In Group-A, after sedation with detomidine @ 2.5 µg/kg, induction was achieved with propofol @ 4 mg/kg and maintenance with constant rate infusion of (detomidine 2.5 µg/kg/hr + propofol 9.6 mg/kg/hr). Similarly, in Group-B, after sedation with midazolam @ 0.25 mg/kg, induction was done with ketamine @ 4 mg/kg and maintenance with infusion of (midazolam 0.25 mg/kg/hr + ketamine 2.4 mg/kg/hr). Whereas, in Group-C, after sedation with (detomidine1.25 µg/kg + midazolam 0.12 mg/kg), induction was done with (propofol 2 mg/kg + ketamine 2 mg/kg) and maintenance with combination of all drugs (detomidine 1.2 µg/kg/hr + midazolam 0.12 mg/kg/hr + propofol 4.5 mg/kg/hr + ketamine 1.2 mg/kg/hr) using a syringe-driving pump. Anesthetic, clinico-physiological and haematobiochemical parameters were evaluated. A better quality anesthesia with rapid and smooth induction, excellent muscle relaxation and rapid recovery was noticed in group C than group A and B. The statistical analysis indicated significant differences (p<0.05) for heart & respiratory rates, diastolic arterial pressure, partial pressure of oxygen and oxygen hemoglobin saturation among or within all groups except within group C. However, non-significant differences (p>0.05) were observed among or within all groups for packed cell volume, total erythrocyte count, total plasma protein and liver & renal function parameters. In conclusion, total intravenous anesthesia maintained with detomidine-midazolam-propofol-ketamine proved to be the best drug combinations taking into account the anesthetic, clinico-physiological and haematobiochemical parameters during pain management.

K1 Detomidine, midazolam, propofol, ketamine, constant rate infusion, goat PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=VS-20-0052