RT Journal
T1 CURATIVE POTENTIAL OF QUERCETIN AGAINST CARBON TETRA CHLORIDE-INDUCED HEPATOTOXICITY IN WISTAR RATS
A1 S. Mushtaq
A1 L. Naz
JF Journal of Animal and Plant Sciences
JO JAPS
SN 1018-7081
VO 30
IS 6
SP 1408
OP 1414
YR 2020
FD 2020/08/03
DO DOI https://doi.org/10.36899/JAPS.2020.6.0162
AB <p>Several studies have revealed that extensive metabolic involvement of liver has rendered the liver susceptible against the xenobiotics&rsquo; devastating effects. Serving as the most potent oxidative stress mediated hepatotoxic agent via reductive CYP2E1 mediated activation, CCl<sub>4</sub>&nbsp;leads to trichloromethyl-radical (CCl<sub>3</sub><sup>-</sup>) and trichloromethyl peroxy (CCl<sub>3</sub>OO<sup>-</sup>) radicals&rsquo; production with subsequent hepatocyte-damage progression. The present investigation was therefore, aimed to investigate the potential of a dietary flavonol, Quercetin against CCl<sub>4</sub>&nbsp;induced chronic hepatotoxicity. 60-days experimental protocol was conducted using 24 male Wistar rats. Animals were divided into four groups. I; Control, II; (CCl<sub>4</sub>-treated) received 0.8 ml/kg BW twice weekly, III; (CCl<sub>4</sub>+Quercetin treated) received CCl<sub>4</sub>, 0.8 ml/kg BW twice weekly and 1 ml/kg quercetin extract (daily, p.o.) and IV; (Quercetin treated) received 1 ml/kg quercetin extract (daily, p.o.). Aspartate Aminotransferase, Alanine aminotransferase, Alkaline Phosphatase, Bilirubin, Malondialdehyde were assessed. Antioxidant evaluation (Superoxide Dismutase, Glutathione, and Catalase) and hepatic histopathological investigation was done. The ALT, AST and Bilirubin levels were significantly reduced in the CCl<sub>4</sub>+Quercetin-treated group as compared to the CCl<sub>4</sub>-treated group. Significant elevation was observed in the SOD, GSH and Catalase levels in the CCl<sub>4</sub>+Quercetin-treated group as compared to the CCl<sub>4</sub>-treated group. Quercetin administration with CCl<sub>4</sub> resulted in reversal of the hepatotoxicity features through reduction in the elevated-enzymes level, lipid peroxidation as well as through raising the decreased antioxidant levels to near normal.</p>
K1 Quercetin, CCl4, hepatotoxicity
PB Pakistan Agricultural Scientists Forum
LK https://thejaps.org.pk/AbstractView.aspx?mid=VS-19-0066