RT Journal T1 EFFECT OF NABUMETONE ON CELLULAR IMMUNE RESPONSES IN MICE A1 K. Naveed A1 A. Javeed1 A1 M. Ashraf A1 A. Riaz A1 S. Khurram A1 A. Sattar A1 A. Ghafoor JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 30 IS 6 SP 1395 OP 1401 YR 2020 FD 2020/08/03 DO DOI https://doi.org/10.36899/JAPS.2020.6.0160 AB

Nabumetone is used to control pain and inflammation in rheumatoid arthritis. It works through inhibition of cyclo-oxygenases (COX), especially COX-2. In the current study, Nabumetone immunomodulatory effect was detected on cellular immunity in mice. The control group was administered normal saline orally as placebo. Nabumetone was administered orally in two treatment groups 14mg/kg and 28mg/kg, respectively by gavage needle. Macrophage engulfment, delayed type hypersensitivity (DTH), nitric oxide measurement and cyclophosphamide induced neutropenia assays were used to evaluate the immunomodulatory effects. In DTH, there was more thickness of the skin in control than Nabumetone treatment groups (p≤0.05). In the macrophage engulfment assay, a significant decrease (p≤0.05) in engulfment percentage was observed in treatment groups. In cyclophosphamide induced neutropenia, the levels of TLC and DLC were higher in the control group (p≤0.05). In the nitric oxide measurement assay, there was a significant reduction in nitric oxide production at higher doses of Nabumetone (p≤0.05). Therefore, it is concluded that Nabumetone suppress cellular immune responses in mice.

K1 Nabumetone, Cellular immunity, Nitric oxide, Macrophages PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=VS-18-0054