RT Journal T1 EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF SALSOLA IMBRICATA FORSSK IN RATS A1 K. H. Janbaz A1 N. Aslam1 A1 I. Imran A1 Q. Jabeen JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 31 IS 3 SP 862 OP 867 YR 2020 FD 2020/11/20 DO DOI https://doi.org/10.36899/JAPS.2021.3.0276 AB

Salsola imbricata has folkloric repute in the treatment of painful and inflammatory conditions. Therefore, present study was undertaken to assess the anti-inflammatory, analgesic and antipyretic activities of aqueous-ethanol crude extract of S. imbricata (Si.Cr) using models of carrageenan-induced paw edema, 4% NaCl-mediated abdominal writhing, formalin-induced paw licking and brewer’s yeast-mediated pyrexia in rats. The Si.Cr (100, 300 and 500 mg/kg, p.o.) significantly (p<0.001) inhibited carrageenan-induced paw edema in rats as compared to the saline treated control group. It inhibited writhes induced by intraperitoneal injection of 4% NaCl (p<0.001) as compared to the control group. In the first phase of formalin-induced paw licking test, Si.Cr (100 and 300 mg/kg) did not cause significant inhibition of nociception in rats, but at the dose of 500 mg/kg, it produced significant (p<0.05) reduction in time of licking paw by rats. Oral administration of Si.Cr (100, 300 and 500 mg/kg) reduced time of licking paw during the second phase of the formalin test. In addition, Si.Cr exhibited significant (p<0.001) antipyretic activity in brewer’s yeast-induced pyrexia in rats. This study, showing the presence of anti-inflammatory, analgesic and antipyretic activities in Si.Cr, supports uses of the plant in folk medicine.

K1 Chenopodiaceae; carrageenan; formalin test; NaCl writhing test; yeast induced pyrexia PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=Pharm -19-0013