RT Journal T1 EFFECTS OF MANNAN-OLIGOSACCHARIDES ON GROWTH PERFORMANCE, SERUM BIOCHEMICAL INDICES, IMMUNE FUNCTION, AND INTESTINAL MORPHOLOGY IN FATTENING TAN SHEEP A1 Qing Ma A1 Lina Ma A1 Qiufei Jiang A1 Zhengwei Zhao A1 Jin Wang A1 Jinyang Tian JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 34 IS 5 SP 1192 OP 1200 YR 2024 FD 2024/10/22 DO DOI https://doi.org/10.36899/JAPS.2024.5.0801 AB

This study examined the effects of dietary Mannan-Oligosaccharides (MOS) on growth performance, serum biochemical indices, immune function, and intestinal morphology in fattening Tan sheep. Twenty-eight four-month-old male Tan sheep were assigned to four groups and received a basal diet supplemented with 0%, 1%, 2%, or 3% MOS for 56 days following a 14-day adaptation period.Results indicated that MOS supplementation significantly increased average daily gain (ADG) in a dose-dependent manner (P ≤ 0.05). Serum biochemical analyses showed a linear and quadratic reduction in triglyceride (TG) levels, and a linear and quadratic increase in alkaline phosphatase (ALP) levels (P ≤ 0.05). Total cholesterol (TC) levels decreased linearly, whereas urea nitrogen (UN) levels increased linearly with higher MOS levels (P ≤ 0.05). Mannan-Oligosaccharides also enhanced total antioxidant capacity (T-AOC) and catalase (CAT) activity, with both parameters increasing linearly (P ≤ 0.05). Immune function was significantly improved, demonstrated by elevated levels of immunoglobulin A (IgA), interleukin-6 (IL-6), IL-10, and interferon-gamma (IFN-γ) (P ≤ 0.05). Additionally, 2% and 3% MOS groups showed increased immunoglobulin G (IgG) and tumor necrosis factor-alpha (TNF-α) levels (P ≤ 0.05). Linear increases were noted in serum IgG, IgA, IgM, IL-6, and TNF-α levels, while IL-10 and IFN-γ levels exhibited both linear and quadratic increases (P ≤ 0.05).Intestinal morphology analysis revealed significant improvements in jejunal villus height, crypt depth reduction, and the villus-to-crypt ratio, with these parameters showing both linear and quadratic changes in response to increasing MOS levels (P ≤ 0.05). In conclusion, 2% MOS supplementation is recommended for enhanced growth performance, metabolic health, immune function, and intestinal integrity in fattening Tan sheep.

K1 Tan sheep; growth performance; antioxidant; immune function; intestinal morphology PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2024-JAPS-1918