RT Journal T1 URIDINE PROMOTES NEURITE OUTGROWTH IN NEUROBLASTOMA CELLS A1 Jacquelyn Spathies A1 Gordon C. Tucker A1 Britto P. Nathan JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 34 IS 3 SP 740 OP 746 YR 2024 FD 2024/05/31 DO DOI https://doi.org/10.36899/JAPS.2024.3.0760 AB

Neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are the main causes of age-related dementia. These diseases can be due to neuronal cell death and/or impairment of neuronal growth and connections. Giant oyster mushroom (GOM), Pleurotus giganteus, is used as a nootropic to improve cognitive function. GOM can also be used to prevent the onset of dementia. The underlying mechanism behind the medicinal property of GOM is unclear. Previous studies have shown that GOM has a high concentration of uridine. In this study, we examined the effects of uridine on neurite outgrowth in the Neuro-2a (N2a) neuroblastoma cell line. We also examined the effects of various concentrations of uridine on neurite outgrowth in N2a cells. When exposed to uridine, N2a cells produced significantly longer neurite extensions (p≤0.001) and exhibited a significant increase in neurite-bearing cells (p≤0.001). The peak neurite promoting effect of uridine was at 100 𝜇M. Our results suggest uridine promotes neurite outgrowth in N2a cells (p≤0.001). Future studies are required to identify the mechanism(s) behind therapeutic potential of uridine on neurodegenerative diseases.

K1 Uridine, giant oyster mushroom, Pleurotus giganteus, neurite outgrowth, herbal medicine, Neuro2a, nerve regeneration, Alzheimer’s disease, Parkinson’s disease PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2023-JAPS-1472