RT Journal T1 FNDC5 IS THE KEY MOLECULE TO INHIBIT MUSCLE FIBER DEVELOPMENT IN TIBETAN PIGS A1 Xinrui Xie A1 Feifei Yan A1 Haibin Wu A1 Guoxin Wu A1 Yikai Yin A1 Mengqi Duan A1 Yangzom Chamba A1 Peng Shang JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 34 IS 3 SP 791 OP 798 YR 2024 FD 2024/05/31 DO DOI https://doi.org/10.36899/JAPS.2024.3.0765 AB

Differences in muscle fiber development between Tibetan and Yorkshire pigs determine their performance in terms of meat quality, taste, and food value. To investigate the molecular regulation of muscle fiber development by fibronectin type III domain-containing protein 5 (FNDC5), a preliminary study of FNDC5 gene expression in the longissimus dorsi muscle and Leg muscle tissues of Tibetan and Yorkshire Pigs was conducted using RT–qPCR and western blotting. Muscle tissues were sectioned and stained to observe the muscle fiber diameter and area under a microscope. The mRNA and protein expression levels of FNDC5, and the diameter and area of muscle fibers in the longissimus dorsi muscle and Leg muscle tissues of Tibetan pigs were significantly lower than those in Yorkshire Pigs. The results imply that FNDC5 negatively regulates muscle fiber diameter in pigs. The role of FNDC5 in pork quality has important implications for improving pork production efficiency, pork quality, and the sustainable development of the livestock industry.

K1 Pig; FNDC5; Gene expression PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2023-JAPS-1391