RT Journal
T1 EFFECT OF TAXIFOLIN ON DOXORUBICIN-INDUCED OXIDATIVE CARDIAC DAMAGE IN RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL EVALUATION
A1 Mehmet Naci Aldemir
A1 Ali Veysel Kara
A1 Renad Mammadov
A1 Gulce Naz Yazici
A1 Betul Cicek
A1 Bulent Yavuzer
A1 Resit Coskun
A1 Abdullah Sakin
A1 Mine Gulaboglu
A1 Halis Suleyman
JF Journal of Animal and Plant Sciences
JO JAPS
SN 1018-7081
VO 34
IS 1
SP 99
OP 106
YR 2024
FD 2024/01/20
DO DOI https://doi.org/10.36899/JAPS.2024.1.0698
AB <p>Doxorubicin is a widely used anthracycline-derived broad-spectrum antitumoral antibiotic drug. However, cardiotoxicity due to doxorubicin treatment has warranted dose reduction or complete discontinuation in certain cases. The role of oxidative stress in the pathogenesis of doxorubicin-induced cardiotoxicity has been previously demonstrated. Against this background, this study aimed to investigate the protective effect of the potent antioxidant flavone taxifolin against possible oxidative heart damage biochemically and histopathologically induced by doxorubicin. Albino Wistar male rats were divided into three groups: healthy controls (HG), a group given doxorubicin alone (DG), and a group given taxifolin + doxorubicin (TDG). Taxifolin was administered orally at a dose of 50 mg/kg via gavage. Doxorubicin was injected intraperitoneally at a dose of 5 mg/kg. This procedure was repeated for 7 days. The results of the biochemical experiment showed that taxifolin significantly inhibited doxorubicin-induced malondialdehyde increases and glutathione decreases in heart tissues. In addition, taxifolin significantly suppressed the increases in cardiac damage markers, such as serum troponin I, creatine kinase, and creatine kinase-MB, induced by doxorubicin. Taxifolin treatment has also been histopathologically shown to alleviate doxorubicin-induced heart tissue damage. Accordingly, the results of the present study suggest that taxifolin may be useful in the treatment of doxorubicin-induced oxidative heart damage.</p>
K1 Antioxidant, cardiotoxicity, doxorubicin, flavonoid, taxifolin
PB Pakistan Agricultural Scientists Forum
LK https://thejaps.org.pk/AbstractView.aspx?mid=2022-JAPS-726