RT Journal T1 EFFECT OF G.13700A>G AND G.25783C>T IN PIT-1 GENE ON GROWTH TRAITS OF DUROC, LANDRACE, YORKSHIRE PIG A1 Xinxing DONG A1 Ziyu LIU A1 Xiaoyi WANG A1 Qiang CHEN A1 Gaicui BAI A1 Guoxiang LAN A1 Qian WANG A1 Mingli LI A1 Dawei YAN A1 Shaoxiong LU JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 33 IS 6 SP 1286 OP 1291 YR 2023 FD 2023/12/15 DO DOI https://doi.org/10.36899/JAPS.2023.6.0668 AB

Pituitary specific transcription factor-1 (Pit-1) gene is responsible for pituitary development and growth hormone expression, which is considered a pivotal candidate gene for growth in pig. This study aims to detect novel single nucleotide polymorphisms (SNPs) in porcine Pit-1 gene, investigate its effect on growth traits in the Duroc, Landrace and Yorkshire pigs. Two novel polymorphisms were detected, one located in the intron 2 (g. 13700 A>G) and another located in exon 4 (g.25783 C>T) which caused an amino acid change from threonine to methionine (Thr36Met). At g.13700 A>G site, the frequency of A allele was higher than G allele in Duroc, Landrace and Yorkshire. At the g.25783 C>T site, it was remarkable differences in allelic frequencies and genotypic frequencies among the three pig breeds. This study demonstrated the significant genotype effect of Pit-1 on body weights at 70 d, age when reached 30kg, 50kg, 100kg and average daily gain from 30kg to 100kg. According to our results, the novel Pit-1 polymorphisms may be useful in pig selection as molecular markers and required in future studies.

K1 Pit-1, pig , growth traits, polymorphisms PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2022-JAPS-146