RT Journal
T1 NEPHROPROTECTIVE EFFECT OF LEMONGRASS (CYMBOPOGON FLEXUOSUS) AND CELERY (APIUM GRAVEOLENS) BASED DETOXIFYING DRINKS AGAINST CARBON TETRACHLORIDE-INDUCED NEPHROTOXICITY IN ALBINO RATS
A1 Jyoti Bohra Mahar
A1 Sonika Sharma
A1 Rajdeep Kaur
A1 Kiran Grover
A1 Khushdeep Dharni
A1 Usha Nara
JF Journal of Animal and Plant Sciences
JO JAPS
SN 1018-7081
VO 33
IS 4
SP 765
OP 775
YR 2023
FD 2023/08/04
DO DOI https://doi.org/10.36899/JAPS.2023.4.0670
AB <p><span lang="EN-IN">Indigenous plants such as lemongrass and celery are rich sources of nutrients. There is a need to test their efficacy for ameliorating nephrotoxicity. Plant-derived drugs have emerged as alternative medicine. Previous studies have focused only on the formulation of detoxifying drinks but its&nbsp;<em>in vivo</em>&nbsp;studies were not performed. The present research was conducted to formulate and evaluate the nutritional composition and antioxidant potential of detoxifying drink variants and to assess their ameliorative effect on the renal toxicity induced by carbon tetrachloride (CCl<sub>4</sub>) at 0.5ml/kg/day i.p in Wistar albino rats. Different detoxifying drink variants</span><span lang="EN-IN">w</span><span lang="EN-IN">ere prepared by adding 0.5%, 1.0% and 1.5% of lemongrass powder (LG5, LG10 and LG15) and celery powder (CL5, CL10 and CL15) respectively to the standard drink</span><span lang="EN-IN">&nbsp;SD</span><span lang="EN-IN">.&nbsp;</span><span lang="EN-IN">These additions resulted in a significant increase (p&le;0.05) in all the nutritional parameters.&nbsp;<em>In vivo</em></span><span lang="EN-IN">d</span><span lang="EN-IN">ata revealed that CCl<sub>4&nbsp;</sub>induced toxicity by increasing malondialdehyde (MDA) (6.87nmoles/ ml RBC lysate), decreased glutathione concentration (3.44&micro;mole/ml RBC lysate) and attenuated antioxidant enzymes activity (U/mg protein) of SOD (0.82), GPx (5.83) and CAT (1.66). Detoxifying drinks significantly (p&le;0.05) corrected urea, uric acid and creatinine levels in plasma. Group VI and VIII receiving LG15 and CL15 variants of detoxifying drink restored the enzymatic (SOD, GPx and CAT) activity (p&le;0.05) and non-enzymatic parameters (GSH) and attenuated the lipid peroxidation in erythrocyte lysate. The detoxifying drink variant with 1.5% celery powder was equivalent to silymarin (herbal medicine) in protecting the kidney against CCL<sub>4</sub>-induced toxicity.</span></p>
K1 Antioxidant potential; celery; carbon tetrachloride; lemongrass; nephrotoxicity
PB Pakistan Agricultural Scientists Forum
LK https://thejaps.org.pk/AbstractView.aspx?mid=2022-JAPS-110