RT Journal T1 EVALUATION OF THE ANTIOXIDANT EFFECTS AND CYTOTOXIC POTENTIAL OF SELECTED HERBS USED IN TRADITIONAL MEDICINE A1 B. Jovanova A1 T. K. Panovska JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 29 IS 5 SP 1466 OP 1475 YR 2019 FD 2019/10/01 DO DOI NA AB

The present study aims to investigate the bioactive properties of five aromatic herbs: Anethum graveolens L., Artemisia dracunculus L., Artemisia vulgaris L., Satureja hortensis L. and Vanilla planifolia Jacks. ex Andrews. Polyphenolic and flavonoid content were determined by Folin-Ciocalteu method and AlCl3 method, respectively. The antioxidant activity of the extracts was evaluated by DPPH radical scavenging assay, FRAP assay, NSSOH and SSOH assay. Additionally, their cytotoxic potential was investigated by performing the Brine shrimp lethality assay. Obtained results revealed that all samples contain significant amount of phenolic compounds, with Artemisia dracunculus and Satureja hortensis showing highest concentration of polyphenols and flavonoids. Moreover, these extracts also demonstrated strong radical scavenging ability and reducing capacity. Differences between IC50 values in the NSSOH and SSOH assays revealed that Artemisia dracunculus also demonstrated prominent chelating properties. According the Brine shrimp lethality assay, Artemisia vulgaris showed strong cytotoxicity against the Artemia larvae, while Artemisia dracunculus and Satureja hortensis showed moderate cytotoxic potential.

K1 commercial herbs, antioxidant activity, cytotoxic potential, brine shrimp lethality assay PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2019-JAPS-529