RT Journal T1 ANTI-INFLAMMATORY EFFECT OF CARALLUMA EDULIS AGAINST ACUTE AND CHRONIC INFLAMMATION A1 A. M. Minhas A1 Arif-ullah Khan A1 M. M. Ansari JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 28 IS 1 SP 264 OP 269 YR 2018 FD 2018/02/01 DO DOI NA AB

Caralluma edulis (Edgew.) Benth. ex Hk.f. (Asclepiadaceae) is traditionally used for the management of rheumatism. The current study aimed to assess the anti-inflammatory effect of Caralluma edulis, to explain its medicinal use in inflammatory ailments. Caralluma edulis crude extract (Ce.Cr) was investigated in acute (carrageenan and xylene mediated) and chronic (formalin evoked) models of inflammation in mice. Ce.Cr  which shows the presence of alkaloids, glycosides, flavonoids, saponins, phenols, terpenes and tannins caused dose-dependent (100, 300 and 1000 mg/kg) reduction of the carrageenan, xylene and formalin-induced inflammation (P < 0.05, P < 0.001 vs. saline group). At the lower dose of 30 mg/kg it was effective in inhibiting the xylene mediated ear edema. No mortality observed with Ce.Cr upto 5 g/kg. This study reveals that Caralluma edulis possess therapeutic ability to reduce inflammation, hence proving its potential to be used as an alternative medicine in the management of inflammatory disorders and also validate its folkloric use in treatment of rheumatism.

K1 Asclepiadaceae, anti-inflammatory, Caralluma edulis, formalin, carrageenan PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2018-JAPS-32