RT Journal
T1 ANTI-INFLAMMATORY ACTIONS OF BERBERIS LYCIUM (W HOLE PLANT) IN ACUTE AND CHRONIC MODELS OF INFLAMMATION IN MICE
A1 A. M. Minhas
A1 A. U. Khan
A1 G. A. Miana
JF Journal of Animal and Plant Sciences
JO JAPS
SN 1018-7081
VO 28
IS 3
SP 754
OP 760
YR 2018
FD 2018/06/01
DO DOI NA
AB Berberis lycium Royle (Berberidaceae) is used in the traditional system of medicine for the treatment of rheumatism. The purpose of the current study was to evaluate the anti-inflammatory activity of Berberis lycium, to explore its medicinal use in inflammatory ailments. Berberis lycium crude extract ( Bl.Cr) was investigated in acute (carrageenan and xylene mediated) and chronic (formalin evoked) models of inflammation in mice. Bl.Cr tested positive for alkaloids, carbohydrates, flavonoids, glycosides, phenols, proteins, saponins, steroids and tannins. Bl.Cr caused a dose-dependent (10, 30 and 50 mg/kg i.p) reduction against carrageenan-induce paw edema (P < 0.001 vs. saline group). Bl.Cr (10, 30 and 50 mg/kg i.p) decreases xylene-mediated ear edema (30.64, 54.83 and 72.58 % respectively; P < 0.001 vs. saline group) . In chronic inflammation, Bl.Cr (1 0, 30 and 50 mg/kg i.p) exhibited a dose-dependent reduction in inflammation (P < 0.05, P < 0.01, P < 0.001 vs. saline group). Diclofenac sodium (20 mg/kg), a standard drug also showed similar effects (P < 0.01 vs. saline group). These results indicate that Berberis lycium possesses significant anti-inflammatory activity, thus providing scientific evidence for its folkloric use in the treatment of rheumatism. sodium, rheumatism. 2012) . Traditionally, Berberis lycium is used against
K1 Berberis lycium whole plant extract, inflammation models in mice, anti-inflammatory activity, diclofenac
PB Pakistan Agricultural Scientists Forum
LK https://thejaps.org.pk/AbstractView.aspx?mid=2018-JAPS-311