RT Journal
T1 CURRENT APPRAISAL OF THE SUITABILITY OF FOOT-AND-MOUTH DISEASE STRAINS IN TWO COMMONLY USED COMMERCIAL VACCINES FOR CONTROL OF FMD IN PAKISTAN
A1 A.Ahmed
A1 A. Latif
A1 R. Zahra
A1 A. B. Zahur2
A1 U. Farooq
A1 A. Ullah
A1 M. Abubakar
A1 A. Jamil
A1 M. Afzal
JF Journal of Animal and Plant Sciences
JO JAPS
SN 1018-7081
VO 27
IS 2
SP 446
OP 450
YR 2017
FD 2017/04/01
DO DOI N/A
AB <p>Vaccination is the primary tool used to control Foot-and-mouth Disease (FMD) in Pakistan. FMD virus mutates regularly in the field and new sub-serotypes continue to emerge. For vaccine to be effective, the vaccine should contain viruses that induce immune response to neutralize the circulating field viruses. This study was undertaken to evaluate if the two commonly used imported FMD vaccines produce sufficient antibodies to neutralize circulating field FMD isolates. Pooled sera from 5 buffalo calves raised against vaccine I and II was used in the serum neutralization test to neutralize 7 field strains of FMD virus serotypes A, O and Asia-1.The field strains of FMD virus were better neutralized with vaccine I than vaccine II. Serotype O and Asia-1 field strains were effectively neutralized with vaccine I antisera. However, low serum neutralization titres were observed against serotype A field isolates suggesting that serotype A strains present in both vaccines need to bebetter matchedwith field strains for effective protection.</p>
K1 Foot-and-mouth Disease, vaccines, field strains, vaccine matching, serum neutralization test
PB Pakistan Agricultural Scientists Forum
LK https://thejaps.org.pk/AbstractView.aspx?mid=2017-JAPS-57