RT Journal T1 THE EFFECTS OF GINKGO BILOBA LEAF EXTRACT ON METABOLIC DISTURBANCES ASSOCIATED TO ALLOXAN-INDUCED DIABETIC RATS A1 M. Naseem1 A1 M. Q. Zaman A1 H. Nazih A1 K. Ouguerram A1 I. Rabbani A1 H. Zaneb A1 T. Yaqoob A1 H. U. Rehman A1 J. Michel A1 S. K. Tahir A1 M. S. Yousaf A1 K. A. Majeed A1 M. S. Hussain JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 26 IS 3 SP 627 OP 635 YR 2016 FD 2016/06/01 DO DOI NA AB

Ginkgo biloba leaf extract (GBE) considered one of the most effective therapeutic herbs. We evaluated anti-diabetic activities of GBE in rats. Rats were fed highly-fat diet for two weeks and divided into three groups (n=8): Non-diabetic control group (CG), Diabetic group (DG), Diabetic+100mg/kg GBE group (D+GBE). On 14th day, the rats were kept in overnight-fasting and administered single intra-peritoneal injection of alloxan-monohydrate (120-130mg/Kg body weight (BW). BW and blood glucose were measured weekly up to 14th week. Fasting/basal blood samples were collected for the biochemical analyses. Liver, skeletal muscle and adipose tissue were also collected for mRNA gene expressions (GLUT-4, IRS-1, IR, PEPCK, SREBP-1c, FAS, PPAR-α, PPAR-γ, TNF-α). Significant reduction in BW was found in D+GBE group at week 14. Glycemia became normalized as an effect of treatment. GBE significantly decreased serum glucose, urea and ALT concentrations. We observed significant higher catalase and lower malondialdehyde levels in D+GBE group. GBE significantly increased HDL-Cholesterol and reduced triglycerides and VLDL-Triglycerides levels. GBE showed up-regulation for hepatic IRS-1 and down-regulation for PEPCK, however, up-regulation for GLUT-4 and PPAR-α found in muscle. Treatment decreased TNF-α expression in liver and adipose tissue. GBE has anti-diabetic mediated by a modulating effect on involved key genes.

K1 Alloxan, Carbohydrate and lipid metabolism, Diabetes mellitus, Ginkgo biloba leaf extract, Rats PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2016-JAPS-86