RT Journal
T1 NOVEL 16-BP INSERTION/DELETION VARIANT OF ZNF132 GENE AND ITS INFLUENCE ON GROWTH TRAITS IN GOATS
A1 X. Y. Wang
A1 Q. Yang
A1 J. Luo
A1 Y. Wang
A1 Q. Feng
A1 Z. H. Zhang
A1 C. Z. Lei
A1 H. Chen
A1 X. Y. Lan
JF Journal of Animal and Plant Sciences
JO JAPS
SN 1018-7081
VO 26
IS 6
SP 1813
OP 1818
YR 2016
FD 2016/12/01
DO DOI NA
AB <p><a id="OLE_LINK1" name="OLE_LINK1"></a>Zinc finger protein 132 (ZNF132) is a transcriptional repressor and plays an important role in animal production traits.&nbsp;<a id="OLE_LINK9" name="OLE_LINK9"></a>Insertion/deletion (indel) polymorphisms are relatively simple and effective DNA markers.<a id="OLE_LINK10" name="OLE_LINK10"></a>&nbsp;The objective of this study was to explore the potential novel indel variants within the goat&nbsp;<em>ZNF132</em>&nbsp;gene, as well as to evaluate their effects on growth traits.&nbsp;<a id="OLE_LINK11" name="OLE_LINK11"></a>A novel 16-bp indel was first verified in a 5&prime; untranslated region (UTR) of the&nbsp;<em>ZNF132</em>&nbsp;gene, and three genotypes were detected.&nbsp;<a id="OLE_LINK19" name="OLE_LINK19"></a>The minor allelic frequencies were 0.160 and zero in the Hainan black goat (HNBG) and Guanzhong dairy goat (GZ) breeds, respectively. Additionally, there were significant differences in the distribution of genotypic and allelic frequencies between these two breeds (<em>P</em>&lt; 0.01).&nbsp;<a id="OLE_LINK2" name="OLE_LINK2"></a>An association analysis revealed that the 16-bp novel indel was significantly associated with the body length of the HNBG breed (<em>P=</em>0.046), and that the individuals with genotype II exhibited the shortest body length, suggesting that the 16-bp indel significantly affected growth traits.&nbsp;These findings could extend the spectrum of genetic variations of the&nbsp;<em>ZNF132</em> gene and provide a valuable theoretical basis via indel markers for marker-assisted selection (MAS) in goat breeding and genetics.</p>
K1 Goat; Zinc finger protein 132 (ZNF132) gene; insertion/deletion (indel) polymorphism; Growth traits;  Association
PB Pakistan Agricultural Scientists Forum
LK https://thejaps.org.pk/AbstractView.aspx?mid=2016-JAPS-237