RT Journal T1 URINARY BLADDER RELAXANT EFFECT OF ARTEMISIA VULGARIS AND ASPALATHUS LINEARIS A1 Arif-ullah Khan A1 A. H. Gilani JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 25 IS 6 SP 1779 OP 1781 YR 2015 FD 2015/12/01 DO DOI NA AB

In isolated rabbit urinary bladder preparations, Artemisia vulgaris (Av.Cr) crude extract inhibited the contractions produced by carbachol (CCh, 1 µM) and high K+ (80 mM) in a  concentration-dependent (0.03-10 mg/mL) manners. The crude extract of Aspalathus linaeris (Al. Cr) relaxed the contractions produced by low K+ (25 mM) at concentration range of 0.3-1.0 mg/mL, having moderate inhibitory effect on contractions produced by K+ (80 mM). Contractions induced by low K+ were partially antagonized by glibenclamide (3 µM). These results indicate that urinary bladder relaxation produced by Artemisia vulgaris extract is mediated via dual, anticholinergic and Ca++ antagonist mechanisms, while that of Aspalathus linaris via dominant KATP channel opening and weak Ca++ channel blockade pathways. Thus the present study reveals the Artemisia vulgaris and Aspslathus linaeris medicinal usefulness in hyperactive bladder disorders

K1 Artemisia vulgaris, Aspalathus linaris, urinary bladder relaxation PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2015-JAPS-239