RT Journal T1 ANTI-HYPERCHOLESTEROLEMIC AND ANTI-ATHEROGENIC ACTIVITY OF Terminalia chebula FRUIT IN NORMAL AND CHOLESTEROL FED RABBITS A1 K. M. Anjum A1 U. Sayyed A1 Aziz Ullah A1 M.S. Mughal A1 A. Yaqub A1 M.A. Rashid A1 M. Z. Yousaf JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 24 IS 6 SP 1618 OP 1622 YR 2014 FD 2014/12/01 DO DOI NA AB

Over the centuries plants have been effectively used as a potent source of traditional medicine. Present experiment was aimed to evaluate the hypocholesterolemic and anti-atherogenic effect of feeding Terminalia chebula powder (TCP)in rabbits. A total of (n=20) rabbits were assigned to four treatment groups with n=5 animals in each group. Experimental treatments received Normal Saline (NS); T. chebula powder (TCP), high fat diet (HFD) and high fat diet plus T. chebula powder (HFDTCP). Blood samples were taken on a weekly basis to diagnose the effects of test drug on serum Total Cholesterol (TC), LDL, HDL, Triglycerides (TG) and Atherogenic Index. All the parameters were measured in mg/dl except the atherogenic index measured in units. In HFD rabbits TC (362.59±6.00), LDL (262.59±6.12) triglycerides (258.7±2.90) and atherogenic index (13.50±1.20) was higher (p <0.05), while HDL (25.73±1.09) was significantly reduced to an alarming level at the end of eight weeks. When HFD rabbits were treated with TCP for eight weeks, TC (132.60±4.93), LDL (89.13±2.75), Triglycerides (125.86±9.06) and atherogenic index (1.54±0.03) reduced significantly and increased (p <0.05) the HDL (52.10±1.50). It was therefore concluded that that T. chebula powder can safely be used to reduce bad cholesterol (LDL) and to enhance good cholesterol (HDL). 

K1 Medicinal plants, Terminalia chebula, HDL, LDL, Hypercholesteremia, Atherogenic Index PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2014-JAPS-231