RT Journal T1 INFLUENCE OF INCREASING FLUORIDE DOSE RATES ON SELECTED LIVER AND KIDNEY ENZYMES PROFILE IN DOMESTIC CHICKEN (Gallus domesticus) A1 K. M. Anjum A1 M.S. Mughal A1 U. Sayyed A1 A. Yaqub A1 A. Khalique A1 M.A. Rashid A1 M. Z. Yousaf A1 N. Mumtaz JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 24 IS 1 SP 77 OP 80 YR 2014 FD 2014/02/01 DO DOI NA AB

Fluoride has been considered to cause hepatic and renal tissue damages in animals and humans. The present study investigated the effect of varying concentrations of fluoride on hepatic and renal enzyme profile in domestic chicken (n=80). Chicken were distributed into 4 groups. Group A was kept unexposed while group B, C and D were exposed to 10, 20 and 30 µg/g body weight of NaF respectively on weekly basis for four weeks. Alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine amino-transferase (ALT) and bilirubin were determined as indicators of liver function test (LFT), while uric acid was as a parameter for renal function test (RFT). All LFT and RFT parameters showed high values (P< 0.05) after one, two three and four weeks in all groups. 579.4 ± 1.55, 355.0 ± 2.13, 246.2 ± 2.45 and 0.83 ± 1.46 were the ALP, AST, ALAT and bilirubin values for LFT and uric acid was 6.74 ± 2.92 in D group at the end of four weeks. All these results indicate the probability of severe effect on the physiology of the liver and kidneys in the exposed birds.

K1 Fluoride intoxication, domestic chicken, LFT, RFT, bilirubin PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2014-JAPS-12