RT Journal T1 ANTIBODY RESPONSE OF RABBITS TO COMBINED HEMORRHAGIC SEPTICEMIA AND FOOT & MOUTH DISEASE VIRUS VACCINE A1 I. Altaf A1 M. Siddique A1 K. Muhammad A1 M. Irshad A1 M. Z. Khan A1 A. A. Anjum A1 M. Kamran JF Journal of Animal and Plant Sciences JO JAPS SN 1018-7081 VO 22 IS 2 SP 501 OP 504 YR 2012 FD 2012/04/01 DO DOI NA AB

Infectious diseases particularly Foot and Mouth Disease (FMD) & Hemorrhagic septicemia (HS) are challenge for livestock and dairy industry all over the world and cause great economic losses. Vaccination programs using monovalent vaccines against the diseases are effective but the repeated vaccination induces stress to the animals and increase cost of vaccination for the farmer. In this study, efficacy of bivalent FMD+HS vaccine was compared to monovalent FMD and HS vaccines in rabbits. Previously isolated and characterized FMD virus “O” serotype and Pasteurella multocida were used in the experimental design. Alum precipitated FMD, HS and FMD+HS vaccines were prepared and injected in experimental rabbits (6 months of age) at 0 and 14th day. The serum samples were collected on 0, 14, 28, 35 and 48 days post-priming. Antibody titer was measured by Virus Neutralization (V/N) for FMD “O” virus and Indirect Hemagglutination (IHA) test for lipopolysaccharide (LPS) of Pasteurella multocida. The results showed that peak level of Geometric mean antibody titer (50.8 VN units & 40.3 IHA units) was obtained on 35th day in both the monovalent FMD and HS vaccine, respectively whereas in bivalent FMD+HS vaccine peak level of GMT antibody titer (161.3 VN units +50.8 IHA units) was detected on 48th days post-priming. It is concluded that combine bivalent vaccine produced better antibody titer that persisted for longer time.

K1 Food and Mouth Disease, Pasteurella multocida, Monovalent, Bivalent PB Pakistan Agricultural Scientists Forum LK https://thejaps.org.pk/AbstractView.aspx?mid=2012-JAPS-243