EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF SALSOLA IMBRICATA FORSSK IN RATS Authors: K. H. Janbaz, N. Aslam1, I. Imran, Q. Jabeen Journal: Journal of Animal and Plant Sciences (JAPS) ISSN: 1018-7081 (Print), 2309-8694 (Online) Volume: 31 Issue: 3 Pages: 862-867 Year: 2020 DOI: https://doi.org/10.36899/JAPS.2021.3.0276 URL: https://doi.org/https://doi.org/10.36899/JAPS.2021.3.0276 Publisher: Pakistan Agricultural Scientists Forum Abstract:

Salsola imbricata has folkloric repute in the treatment of painful and inflammatory conditions. Therefore, present study was undertaken to assess the anti-inflammatory, analgesic and antipyretic activities of aqueous-ethanol crude extract of S. imbricata (Si.Cr) using models of carrageenan-induced paw edema, 4% NaCl-mediated abdominal writhing, formalin-induced paw licking and brewer’s yeast-mediated pyrexia in rats. The Si.Cr (100, 300 and 500 mg/kg, p.o.) significantly (p<0.001) inhibited carrageenan-induced paw edema in rats as compared to the saline treated control group. It inhibited writhes induced by intraperitoneal injection of 4% NaCl (p<0.001) as compared to the control group. In the first phase of formalin-induced paw licking test, Si.Cr (100 and 300 mg/kg) did not cause significant inhibition of nociception in rats, but at the dose of 500 mg/kg, it produced significant (p<0.05) reduction in time of licking paw by rats. Oral administration of Si.Cr (100, 300 and 500 mg/kg) reduced time of licking paw during the second phase of the formalin test. In addition, Si.Cr exhibited significant (p<0.001) antipyretic activity in brewer’s yeast-induced pyrexia in rats. This study, showing the presence of anti-inflammatory, analgesic and antipyretic activities in Si.Cr, supports uses of the plant in folk medicine.

Keywords: Chenopodiaceae; carrageenan; formalin test; NaCl writhing test; yeast induced pyrexia