EFFECTS OF PYRROLOQUINOLINE QUINONE ON GROWTH PERFORMANCE, ANTIOXIDANT ACTIVITY, AND IMMUNITY IN PLECOGLOSSUSALTIVELIS

Authors: Xu WANG, Yi-tong HAN, Jia-yi ZHANG
Journal: Journal of Animal and Plant Sciences (JAPS)
ISSN: 1018-7081 (Print), 2309-8694 (Online)
Volume: 35  Issue: 4  Pages: 981-990
Year: 2025
DOI: https://doi.org/10.36899/JAPS.2025.4.0084
URL: https://doi.org/https://doi.org/10.36899/JAPS.2025.4.0084
Publisher: Pakistan Agricultural Scientists Forum

Abstract:
<p>The rapid growth of the aquaculture industry has necessitated the exploration of novel feed additives to enhance fish production performance and health status. This study evaluates the effects of pyrroloquinoline quinone (PQQ) on the production performance, antioxidative capacity, and nonspecific immune response of&nbsp;<em>Plecoglossusaltivelis</em>, with a focus on elucidating its functional mechanisms. Through precise control of PQQ supplementation dosages(0.2, 0.4, and 0.6 mg/kg in the diet), the study analyzed its impact on growth metrics, serum biochemical parameters, antioxidant enzyme activities, and intestinal digestive enzyme activities in&nbsp;<em>Plecoglossusaltivelis</em>. Results indicated that PQQ supplementation markedly improved the growth performance of&nbsp;<em>Plecoglossusaltivelis</em>, including final body weight, weight gain rate, specific growth rate, and condition factor (<em>P&lt;</em>0.05). Additionally, PQQ reduced serum triglyceride concentrations (<em>P&lt;</em>0.05) and enhanced antioxidant enzyme activities, including catalase and superoxide dismutase (<em>P&lt;</em>0.05), as well as total antioxidant capacity (<em>P&lt;</em>0.05). Regarding nonspecific immunity, PQQ elevated serum immunoglobulin M levels, lysozyme activity, and complement C3 content (<em>P&lt;</em>0.05). Furthermore, PQQ stimulated intestinal protease activity (<em>P&lt;</em>0.05).These findings demonstrate that PQQ effectively enhances the production performance, antioxidative capacity, and nonspecific immune response of&nbsp;<em>Plecoglossusaltivelis</em>.</p>

Keywords: Pyrroloquinoline quinone (PQQ);Plecoglossusaltivelis; production performance; antioxidative capacity; nonspecific immune response