EFFECTS OF DIFFERENT LEVELS OF FORAGE AND CONCENTRATE ON THE METABOLISM OF GLUCOSE, β-HYDROXYBUTYRATE AND NONESTERIFIED FATTY ACID IN LIVERS OF NONLACTATING GOATS Authors: S. Zhuang, R. Yan, W.C. Dong, T. Zhang G.J. Chang, X. Z. Shen Journal: Journal of Animal and Plant Sciences (JAPS) ISSN: 1018-7081 (Print), 2309-8694 (Online) Volume: 24 Issue: 1 Pages: 135-141 Year: 2014 DOI: NA URL: https://doi.org/NA Publisher: Pakistan Agricultural Scientists Forum Abstract:

The aim of this study was to investigate the effects of different levels of forage and concentrates diets on the metabolism of glucose, β-hydroxybutyrate (BOHB) and nonesterified fatty acid (NEFA) in livers of nonlactating goats. Six catheterized GuanZhong goats (40±2 kg weight) were fed high concentrate diet (HC, 40% hay, 60% concentrate) or high forage diets (HF, 60% hay, 40% concentrate). Blood samples were simultaneously taken from the portal, hepatic and arterial catheters at 0 h, before feeding, 2, 4, 6 and 8 h after feeding. The HC fed goats exhibited higher (P<0.01) plasma glucose concentration and arterial flow accompanied by NEFA, BOHB(P<0.01) and hepatic glucagons concentrations (P<0.10) while NEFA portal flow and BOHB hepatic flow decreased (P<0.05). Glucose portal-arterial concentration difference and hepatic-portal concentration differences in BOHB and NEFA tended to decreased (P<0.10) with increasing NEFA portal and hepatic arterial concentration differences (P<0.05) in HC fed goats. There were no differences in net flow of glucose, BOHB and NEFA across splanchnic tissues, but a decreased net portal absorption in NEFA (P<0.05) accompanied with a tendency for depressing its net PDV plus hepatic uptake (P<0.10). In conclusion, the high concentrates diet may increase hepatic gluconeogenesis in nonlactating goats.

Keywords: Concentrate, Liver, Glucose, Nonesterified fatty acid, β-Hydroxybutyrate, Goat