STUDY OF TECOMELLA UNDULATA G. DON. METHANOLIC EXTRACT AGAINST SARCOPTES SCABIEI L. IN VIVO AND IN VITRO - Khan; M. A.; A. H. Shah A. Maqbol S. B. Khan; U. Sadique; M. Idress (Journal of Animal and Plant Sciences, 2013)
ecomella undulata G. Don. is long been used in ayurvedic system of medicine. The plant has been declared to exhibit diverse pharmacological activities. The antiacarid effect of methanolic extract of Tecomella undulata G. Don. with concentrations of 10 and 20% was evaluated. The extract was applied topically on scabies affected skin of camels, buffalos, goats, dogs and people and the effect was monitored through symptomatic relief and microscopic examination of the mange. The topical application of Tecomella undulata extract (10 and 20%), ivermectin (reference compound) and 100% methyl alcohol (control) on scabies affected buffalos gave 64, 78 ,82 and 8%, on camels 64, 78, 82 and 4%, on dogs 62, 83, 85 and 7%, on goats 58, 73, 81 and 5% protection and on persons 61, 78, 80 and 5% protection, respectively after five weeks. In addition, the effect of Tecomella undulata extract with three different concentrations (i.e. 10, 20, and 30%) was studied to know the duration to be taken to kill Sarcoptes scabiei using in vitro laboratory test. The results revealed that 10, 20 and 30% concentrations of Tecomella undulata extract caused 45, 65, and 80% mortality of the Sarcoptes scabiei mites, respectively. Ivermectin caused 85% and in control treatment 10% mortality of the mite was recorded. It is concluded that Tecomella undulate has effective properties to be used as acaricidal.
Keywords: journal article; Techomela undulata; extract; efficacy; ivermectin and mite