17 M. Andonova Journal of Animal and Plant Sciences JAPS 20202020/03/25 30 3 642-648 1018-7081 https://doi.org/10.36899/JAPS.2020.3.0076 <p>The еffect of&nbsp;<em>Tanacetum parthenium</em>&nbsp;(feverfew) on serum amyloid A (SAA) and free sialic acid (SA) were investigated in dogs. The animals were divided into three groups: healthy dogs (Group I; n=5), dogs infected subcutaneously with 1&times;108 CFU/mL field&nbsp;<em>P</em><em>.&nbsp;</em><em>aeruginosa</em>&nbsp;culture (Group II; n=5) and infected dogs treated with feverfew (90 mg standardised extract, 0.7% parthenolide) (Group III; n=5). Oral phytopreparation (2 capsules daily) intake began from post infection hour 4 and lasted 6 days. SAA concentrations increased insignificantly in infected dogs (16 mg/L) while infected dogs treated with feverfew exhibited more than 100-fold increase between post infection hours 24&ndash;72 vs Group II. Substantial differences (p&lt;0.01) were identified vs Groups I and II at post infection hour 4, 48 and 72, but one day after feverfew discontinuation (day 7), they were not found out. Serum SA was low in controls (1.65&ndash;2.3 mmol/L) increasing by hour 72 in Groups II and III (p&lt;0.01) to 2.8 and 3.49 mmol/L respectively. Positive correlation between both studied markers was present only in infected dogs receiving feverfew (Spearman&rsquo;s coefficient of rank correlation=0.410, P=0.0086, n=40).<em>&nbsp;Tanacetum parthenium</em> is reported to have medicinal activity in our canine skin infection model.</p> dogs, P. aeruginosa, infection, feverfew, serum amyloid A, sialic acid Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=VS-19-0015