17 K. H. Janbaz N. Aslam1 I. Imran Q. Jabeen Journal of Animal and Plant Sciences JAPS 20202020/11/20 31 3 862-867 1018-7081 https://doi.org/10.36899/JAPS.2021.3.0276 <p><em>Salsola imbricata</em>&nbsp;has folkloric repute in the treatment of painful and inflammatory conditions. Therefore, present study was undertaken to assess the anti-inflammatory, analgesic and antipyretic activities of aqueous-ethanol crude extract of&nbsp;<em>S. imbricata</em>&nbsp;(Si.Cr) using models of carrageenan-induced paw edema, 4% NaCl-mediated abdominal writhing, formalin-induced paw licking and brewer&rsquo;s yeast-mediated pyrexia in rats. The Si.Cr (100, 300 and 500 mg/kg, p.o.) significantly (<em>p</em>&lt;0.001) inhibited carrageenan-induced paw edema in rats as compared to the saline treated control group. It inhibited writhes induced by intraperitoneal injection of 4% NaCl (<em>p</em>&lt;0.001) as compared to the control group. In the first phase of formalin-induced paw licking test, Si.Cr (100 and 300 mg/kg) did not cause significant inhibition of nociception in rats, but at the dose of 500 mg/kg, it produced significant (<em>p</em>&lt;0.05) reduction in time of licking paw by rats. Oral administration of Si.Cr (100, 300 and 500 mg/kg) reduced time of licking paw during the second phase of the formalin test. In addition, Si.Cr exhibited significant (<em>p</em>&lt;0.001) antipyretic activity in brewer&rsquo;s yeast-induced pyrexia in rats. This study, showing the presence of anti-inflammatory, analgesic and antipyretic activities in Si.Cr, supports uses of the plant in folk medicine.</p> Chenopodiaceae; carrageenan; formalin test; NaCl writhing test; yeast induced pyrexia Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=Pharm -19-0013