17 Caglar OKULMUS Abdurrahman Anil CAGIRGAN Yakup YILDIRIM Ozge Sevinc KORKMAZ AKAR Ali KUCUK Journal of Animal and Plant Sciences JAPS 20252025/07/29 35 4 1068-1075 1018-7081 https://doi.org/10.36899/JAPS.2025.4.0091 <p>The Orthohepevirus A strain of hepatitis E virus (HEV) is one of the world's leading zoonotic viruses and poses significant public health concerns. HEV susceptibility has been demonstrated in a wide range of animal species and have the capacity to transmit the virus to humans. However, the contribution of Orthohepevirus A serotypes to HEV epidemiology remains poorly understood. Blood serum samples were collected from 188 domestic animals from different farms selected by random sampling in Burdur province of T&uuml;rkiye. The animal group consisted of 22 horses, 22 donkeys, 30 sheep, 25 goats, 27 cattle, 35 cats and 27 dogs. An overall HEV seroprevalence of 4.79% was observed. The presence of HEV antibodies in goats, horses, and donkeys was detected for the first time in T&uuml;rkiye. Statistical tests performed to determine the difference between seropositivity rates according to animal species were found significant at p &le; 0.05. Orthohepevirus A RNA was undetectable in all samples using gel-based nested RT-PCR. In this first report on HEV in farm animals in T&uuml;rkiye, the presence of HEV antibodies suggests that farm animals may have an important role in spreading infection.</p> Domestic animals, Hepatitis E virus, HEV antibodies, Türkiye, Zoonotic potential Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=2025-JAPS-7