17 dehong tian kai zhao Baicheng Zhou Buying Han Xue Li Fei Tian Delin Qi Journal of Animal and Plant Sciences JAPS 20232023/12/13 33 6 1474-1489 1018-7081 https://doi.org/10.36899/JAPS.2023.6.0687 <p><span lang="EN-US">Qaidam Cashmere goat is one of the few animals that can survive in the harsh environment of the Qinghai-Tibet Plateau and the adjacent alpine areas. It has a strong adaptability, thus shaping the genetic diversity of goat phenotype, morphology, physiology and other aspects. However, the molecular basis behind these genetic mechanisms remains unclear. Here, we conducted genome-wide studies of genetic variation in two different morphologies and geographical coordinates in indigenous Chinese goats to identify selective signaling in genomic regions. In the present study,&nbsp;</span><span lang="EN-US">w</span><span lang="EN-US">e resequenced 10 high-altitude Chinese indigenous goat breeds and compared them with low-altitude goats.</span><span lang="EN-US">By combining &theta;&pi; and Fst values, we identified 1277 overlapping selection regions that may contribute to the wool fiber traits, reproductive performance, and high-altitude adaptation of goats.</span><span lang="EN-US">Candidate genes enriched in selected regions are associated with the phenotypes in cashmere fiber traits (IGFBP3, TNF, ROCK1, WNT10B, KITLG), reproduction traits (CAMK2D, IL-18, ESR1, ANAPC13), body size (POMC), hypoxic adaptation (TH, ACER1, GNB1, HIF1A) and disease (IL-10).&nbsp;</span><span lang="EN-US">This study provided valuable genetic information for the basis of biological characteristics and genetic improvement of br</span><span lang="EN-US">eeds.</span></p> cashmere goat, whole-genome resequencing, adaptability, candidate genes Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=2022-JAPS-693