17 Jae-Suk Choi Joo Wan Kim Go-Woon Jung Dong-Chan Park Hyung-Rae Cho Sae Kwang Ku Jae-Hak Sohn Journal of Animal and Plant Sciences JAPS 20182018/04/01 28 2 660-668 1018-7081 NA <p>The primary objective of the present study was to determine the effects of &#946;-glucan derived from <em>Aureobasidium</em> on diabetes and diabetic hyperlipemia in an animal model of streptozotocin (STZ)-induced diabetes. &#946;-glucan was orally administered to STZ-induced diabetic hyperlipemic Sprague-Dawley (SD) rats for 4 weeks beginning at 25 days after STZ administration (late diabetic hypoglycemic and hyperlipemia model). Changes in body weight were recorded throughout the study and blood glucose and serum low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglyceride, and total cholesterol (T-CHOL) levels were measured at 28 days after &#946;-glucan administration. The &#946;-glucan results were compared with those from rats that received Simvastatin (10 mg/kg). Following the occurrence of STZ-induced diabetes, the STZ control group exhibited decreases in body weight and serum HDL levels in conjunction with increases in blood glucose, serum LDL, triglyceride, and T-CHOL levels compared to the intact control group. However, serum LDL, triglyceride, and T-CHOL levels dramatically decreased in the STZ groups that received &#946;-glucan (62.5 and 125 mg/kg). The present results suggest that &#946;-glucan derived from <em>Aureobasidium</em> does not exert hypoglycemic effects in an SD rat model of STZ-induced diabetes. However, &#946;-glucan did have favorable effects in terms of attenuating complications related to diabetic hyperlipemia at a dose of 62.5 mg/kg/day or more. Therefore, &#946;-glucan may be a candidate as a novel hypolipemic agent designed specifically to treat diabetic complications related to hyperlipemia regardless of the severity of disease.</p> Hypoglycemic effect, hypolipemic effect, β-glucan, rats Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=2018-JAPS-240