17 M. Faheem N. Jahan K. P. Lone Journal of Animal and Plant Sciences JAPS 20162016/04/01 26 2 514-522 1018-7081 NA <p>Bisphenol-A (BPA) is a xenoestrogen that mimics the action of natural estrogen, estradiol-17&beta;, and can disrupt the endocrine system. Present study was designed to investigate histopathological effects of BPA on some vital organs of major carp,&nbsp;<em>Catla catla</em>. Fish were exposed to various sub-lethal concentrations (1 to 4 ppm) of BPA in a semi-static system for 15 days.&nbsp; After the stipulated time, liver, kidneys and gills were dissected out and fixed immediately in 10 % buffered formalin. After embedding in paraffin wax, 5 micron thick sections were cut and stained with H &amp; E and PAS stains.&nbsp; In liver, BPA caused central vein congestion, inflammation, edema, degeneration and necrosis of hepatocytes. Kidney anomalies included obliteration of bowmen&rsquo;s space, shrinkage and degeneration of tubules and glomerulus. Gills responded to BPA stress by hyperplasia of mucous cells, clubbing and degeneration of secondary-lamellae. The present study revealed that BPA causes degenerative changes in various vital organs of&nbsp;<em>C. catla&nbsp;</em>and severity of histological changes were dose-related.</p> Histopathology, Endocrine disrupting chemicals, Bisphenol-A, Catla catla Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=2016-JAPS-69