17 Arif-ullah Khan A. H. Gilani Journal of Animal and Plant Sciences JAPS 20152015/12/01 25 6 1779-1781 1018-7081 NA <p>In isolated rabbit urinary bladder preparations,&nbsp;<em>Artemisia vulgaris&nbsp;</em>(Av.Cr) crude extract inhibited the contractions produced by carbachol (CCh, 1 &micro;M) and high K+ (80 mM) in a &nbsp;concentration-dependent (0.03-10 mg/mL) manners. The crude extract of&nbsp;<em>Aspalathus linaeris&nbsp;</em>(Al. Cr) relaxed the contractions produced by low K+ (25 mM) at concentration range of 0.3-1.0 mg/mL, having moderate inhibitory effect on contractions produced by K+ (80 mM). Contractions induced by low K+ were partially antagonized by glibenclamide (3 &micro;M). These results indicate that urinary bladder relaxation produced by&nbsp;<em>Artemisia vulgaris</em>&nbsp;extract is mediated via dual, anticholinergic and Ca++ antagonist mechanisms, while that of&nbsp;<em>Aspalathus linaris&nbsp;</em>via dominant KATP channel opening and weak Ca++ channel blockade pathways. Thus the present study reveals the&nbsp;<em>Artemisia vulgaris&nbsp;</em>and<em>&nbsp;Aspslathus linaeris</em> medicinal usefulness in hyperactive bladder disorders</p> Artemisia vulgaris, Aspalathus linaris, urinary bladder relaxation Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=2015-JAPS-239