17 U. Saleem B. Ahmad M. Ahmad K. Hussain N. I. Bukhari A. A. Anjum Journal of Animal and Plant Sciences JAPS 20142014/04/01 24 2 450-454 1018-7081 NA <p><em>Euphorbia helioscopia&nbsp;</em>L. has been investigated for antibacterial, antifungal, antiviral and vasodepressor activities. The study was designed to probe into the reproductive toxicity (teratogenicity) potential of&nbsp;<em>Euphorbia helioscopia&nbsp;</em>L. in albino mice. Toxicity of latex and methanol extract of leaves (10, 50, 80, 100 and 120 &micro;g/200 &micro;L) was evaluated in white leghorn chicken embryos (5th day) using chorioallantoic membrane route (n = 30 for each experiment i.e. latex &amp; extract, or 5 per dose and 5 as control group). Teratogenic potential of latex (n= 5) and extract (100, 300, 500, 700, 1000, 1500 and 2000 mg/kg body weight, n= 40, or 5 per concentration and 5 as control group) was evaluated in pregnant albino mice on 7th day of gestation using intra-peritoneal route. Both latex and leave extract checked in chicken embryos were safe. LD50 calculated with TSK software was 1397 mg/kg body weight for methanol extract of leaves observed in albino mice. The rest of the experimental concentrations were non-lethal in mice without any observable malformation. It is concluded that the concentration (administered parentally) less than LD50 is devoid of teratogenic effects in pregnant female mice and chicken embryos.</p> Euphorbia helioscopia, Chicken Embryo, Mice, Teratogenicity, Toxicity Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=2014-JAPS-64