PHARMACOKINETIC STUDY OF ENROFLOXACIN IN TIANFU GEESE

F. Shi H. Tang W. Xie A. Anees Z. Yang X. Zhang PHARMACOKINETIC STUDY OF ENROFLOXACIN IN TIANFU GEESE

Journal of Animal and Plant Sciences

JAPS

2014

2014/02/01

24 1 113-119 1018-7081

The pharmacokinetic behavior of enrofloxacin (EF) was investigated in geese after oral (p.o.) and intravenous (i.v.) administrations of a single dose of 20 mg/kg body weight. Plasma concentrations of EF and its active metabolite, ciprofloxacin, were determined by high performance liquid chromatography fluorescence method. Plasma concentrations versus time were analyzed by non-compartmental method. The elimination half-life and area under drug concentration-time curve from zero to infinity of EF after i.v. administration were 3.32 ± 0.43 h and 45.73 ± 5.74 mg/L·h, respectively. After p.o. administration, EF was absorbed fast and the maximum plasma concentration of 3.86 ± 0.36 mg/L reached at 2.14 ± 1.10 h. The concentration-time profile of EF showed a double peak-shaped curve, indicating the possibility of enterohepatic recirculation of EF in geese. The bioavailability for EF after p.o. administration was 78.09 ± 25.76%. Seldom ciprofloxacin was detected in the plasma both after i.v. and p.o. administrations, indicating low transformation rate from EF to ciprofloxacin in geese. Taking into account the efficacy indices obtained, a single p.o. dose of 20 mg/kg of EF would be adequate for treating infections caused by highly susceptible bacteria in geese. pharmacokinetics; enrofloxacin; geese; intravenous administration; oral administration Pakistan Agricultural Scientists Forum

https://thejaps.org.pk/AbstractView.aspx?mid=2014-JAPS-17