17 Chunmei Guo Shuqing Liu Yimeng Guo Yuling Yin Jintao Lin Xin Chen… Ming-Zhong Sun Journal of Animal and Plant Sciences JAPS 20142014/06/01 24 3 926-935 1018-7081 NA <p>The antiplatelet and antiradical activities of 8 dietary flavonoid phytochemicals were investigated and compared. Quercetin, rutin, isoquercitrin, hesperetin, naringenin, hesperidin, naringin and icariin inhibited ADP-induced rat platelet aggregation by 68.33&plusmn;2.43%, 55.34&plusmn;2.09%, 52.27&plusmn; 4.65%, 50.80&plusmn;7.03%, 33.07&plusmn;2.09%, 31.28&plusmn;4.65%, 22.91&plusmn;1.68% and 20.94&plusmn;3.20%, respectively. Only quercetin, rutin and isoquercitrin showed clear scavenging HO&middot; radical activity. Function-structure analysis indicated 1) flavonoids with more free phenolic hydroxyl groups showed relative higher antiplatelet and antiradical activities; 2) substitution of 7-OH of A ring affected antiplatelet capacities of flavanones apparently; 3) free 3-OH of C ring was important for both the antiplatelet and antiradical activities of flavonol (quercetin) and flavones (rutin, isoquercitrin); 4) C ring C2-C3 double bond and B ring 3&rsquo;-4&rsquo;orthodihydroxy might be important for its antiradical function. This study provides certain clues for evaluating a favorable dietary flavonoid drugs from our foods in prevention and treatment of related diseases associated with platelet aggregation and hyroxyl radical oxidation.</p> Flavonoids, Antiplatelet, Antiradical, Function, Structure Pakistan Agricultural Scientists Forum https://thejaps.org.pk/AbstractView.aspx?mid=2014-JAPS-130