[{
  "type": "article-journal",
  "title": "THERAPEUTIC POTENTIAL OF OZONE AND L-CARNITINE COMBINED ADMINISTRATIONS AGAINST EXPERIMENTALLY-INDUCED ACETAMINOPHEN",
  "author": [
    {
      "family": "Paldir",
      "given": ""
    },
    {
      "family": "2",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2020]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "31",
  "issue": "4",
  "page": "981-987",
  "DOI": "https://doi.org/10.36899/JAPS.2021.4.0294",
  "abstract": "<p>Acetaminophen is a widely used medicine with antipyretic and analgesic effects. N-acetyl-P-benzoquinoneimine accumulation after a high-dose of acetaminophen leads to hepatotoxicity, depletion of glutathione stores, and suppression of the antioxidant defense mechanism. As a result, N-acetyl-P-benzoquinoneimine cannot be eliminated from the body and hepatotoxicity occurs. In this study, the effects of the separate and combined use of ozone and L-carnitine in high-dose acetaminophen induced hepatotoxicity was investigated. A total of 56 female Wistar albino rats were randomly divided into 8 groups of seven rats. Acetaminophen was administered orally as a single dose to induce liver damage, and 0.5 mg/kg of 95% oxygen plus 5% ozone gas mixture was administered intraperitoneally. After 1-hour APAP administration, L-carnitine were given 500 mg/kg by intraperitoneally. Serum and tissue oxidant/antioxidant parameters were measured to deduce their combined effect. ANOVA and Tukey&rsquo;s multiple comparison test were used for statistical analysis. Acetaminophen+L-carnitine+ozone administration caused a significant decrease in the levels of serum malondialdehyde, total oxidant level, aspartate aminotransferase, alanine aminotransferase, and tissue malondialdehyde, total oxidant status levels, while it led to a significant increase in the levels of tissue and serum total antioxidant levels. Nonetheless, a clear evidence of superiority over the sole use of ozone or L-carnitine in acetaminophen induced hepatotoxicity was not present. It was concluded that ozone, L-carnitine and ozone+L-carnitine treatments in acetaminophen induced hepatotoxicity protected the organism against the harmful effects of free radicals and activated the antioxidant mechanism by suppressing oxidative stress.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=VS-20-0020"
}]