[{
  "type": "article-journal",
  "title": "EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF SALSOLA IMBRICATA FORSSK IN RATS",
  "author": [
    {
      "family": "Janbaz",
      "given": ""
    },
    {
      "family": "Aslam1",
      "given": ""
    },
    {
      "family": "Imran",
      "given": ""
    },
    {
      "family": "Jabeen",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2020]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "31",
  "issue": "3",
  "page": "862-867",
  "DOI": "https://doi.org/10.36899/JAPS.2021.3.0276",
  "abstract": "<p><em>Salsola imbricata</em>&nbsp;has folkloric repute in the treatment of painful and inflammatory conditions. Therefore, present study was undertaken to assess the anti-inflammatory, analgesic and antipyretic activities of aqueous-ethanol crude extract of&nbsp;<em>S. imbricata</em>&nbsp;(Si.Cr) using models of carrageenan-induced paw edema, 4% NaCl-mediated abdominal writhing, formalin-induced paw licking and brewer&rsquo;s yeast-mediated pyrexia in rats. The Si.Cr (100, 300 and 500 mg/kg, p.o.) significantly (<em>p</em>&lt;0.001) inhibited carrageenan-induced paw edema in rats as compared to the saline treated control group. It inhibited writhes induced by intraperitoneal injection of 4% NaCl (<em>p</em>&lt;0.001) as compared to the control group. In the first phase of formalin-induced paw licking test, Si.Cr (100 and 300 mg/kg) did not cause significant inhibition of nociception in rats, but at the dose of 500 mg/kg, it produced significant (<em>p</em>&lt;0.05) reduction in time of licking paw by rats. Oral administration of Si.Cr (100, 300 and 500 mg/kg) reduced time of licking paw during the second phase of the formalin test. In addition, Si.Cr exhibited significant (<em>p</em>&lt;0.001) antipyretic activity in brewer&rsquo;s yeast-induced pyrexia in rats. This study, showing the presence of anti-inflammatory, analgesic and antipyretic activities in Si.Cr, supports uses of the plant in folk medicine.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=Pharm -19-0013"
}]