[{
  "type": "article-journal",
  "title": "IDENTIFICATION AND CHARACTERIZATION OF DIFFERENT POTENTIALLY ANTIBACTERIAL COMPOUNDS FROM A MARINE STREPTOMYCES SP. SP1",
  "author": [
    {
      "family": "Atallah",
      "given": ""
    },
    {
      "family": "El-Mohsnawy",
      "given": ""
    },
    {
      "family": "El-Shouny",
      "given": ""
    },
    {
      "family": "Haroun",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2023]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "33",
  "issue": "1",
  "page": "166-173",
  "DOI": "https://doi.org/10.36899/JAPS.2023.1.060",
  "abstract": "<p>Due&nbsp;to the overuse of antibiotics and the rise in the frequency of multidrug-resistant bacteria (MDR), the development of novel antibiotics is one of the most pressing needs today. In the present study, the marine actinomycete&nbsp;<em>Streptomyces&nbsp;</em>sp. Sp1 was isolated for the first time from Lake Burullus,Nile Delta, Egypt.&nbsp;<em>Streptomyces&nbsp;</em>sp. Sp1 was identified via morphological and biochemical techniques. Furthermore, it was identified on the basis of 16S rRNA gene sequence that was analyzed using the BLAST-N tool (Basic Local Alignment Search Tool-Nucleotides) from the NCBI website (National Center for Biotechnology Information).<em>&nbsp;Streptomyces&nbsp;</em>sp. Sp1 exhibited high antibacterial activity against three serious multidrug resistant pathogens,&nbsp;<em>Listeria monocytogenes</em>,&nbsp;<em>Staphylococcus aureus</em>&nbsp;and&nbsp;<em>Pseudomonas aeruginosa</em>. The potential antibacterial compounds produced by&nbsp;<em>Streptomyces&nbsp;</em>sp. Sp1 were analyzed using gas chromatography-mass spectroscopy (GC-MS). It confirmed the presence of five bioactive compounds; broxyquinoline, 9-aminoacridine, 9,10-anthracenedione, harmine and ricinoleic acid that have different antimicrobial mechanisms.The great antibacterial activity of&nbsp;<em>Streptomyces</em> sp.Sp1 could be explained by combination of the different antimicrobial&nbsp;mechanisms of these compounds.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=Biot-21-0045"
}]