[{
  "type": "article-journal",
  "title": "EFFECT OF Rhabdosciadium anatolyi AND CHLOROGENIC ACID ON SERUM RETINOL, CHOLECALCIFEROL AND PHYLLOQUINONE LEVELS IN EXPERIMENTAL CYCLOPHOSPHAMIDE TREATED RATS",
  "author": [
    {
      "family": "BAKIR",
      "given": ""
    },
    {
      "family": "EKIN",
      "given": ""
    },
    {
      "family": "FIRAT",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2025]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "35",
  "issue": "3",
  "page": "747-755",
  "DOI": "https://doi.org/10.36899/JAPS.2025.3.0063",
  "abstract": "<p><span lang=\"TR\">In this study, the effects of chlorogenic acid (<em>CA</em>), and ethanol extract of&nbsp;<em>Rhabdosciadium anatolyi</em>&nbsp;(<em>R. anatolyi</em>) flowers on the levels of vitamins (retinol, cholecalciferol and phylloquinone) in the serum of experimentally cyclophosphamide (<em>CP</em>)-induced rats were investigated. Wistar-albino female rats (N=48) of 8 weeks old (200-250 g) were divided into six groups of 8 animals each (control (0.9% NaCl), 200 mg/kg&nbsp;<em>CP</em>, 100 mg/kg&nbsp;<em>CA</em>, 300 mg/kg&nbsp;<em>R.anatolyi</em>&nbsp;flowers extract, 200 mg/kg&nbsp;<em>CP</em>&nbsp;+ 300 mg/kg&nbsp;<em>R.anatolyi</em>&nbsp;flowers extract and 200 mg/kg&nbsp;<em>CP</em>&nbsp;+ 100 mg/kg&nbsp;<em>CA)</em>.</span><span lang=\"TR\">At the end of the 7-day study, blood samples were collected from the rats&rsquo; heart and serum was extracted. Retinol, cholecalciferol and phylloquinone levels in the groups were determined simultaneously using simple reversed phase HPLC method. According to the results of statistical analysis, a significant difference (p&lt;0.01, p&lt;0.05) was observed between the control group and the groups treated with 200 mg/kg&nbsp;<em>CP</em>&nbsp;and 200 mg/kg&nbsp;<em>CP</em>&nbsp;+ 300 mg/kg&nbsp;<em>R. anatolyi</em>&nbsp;flower ethanol extract, respectively. In addition, a significant difference (p&lt;0.01) in cholecalciferol levels between control and 200 mg/kg&nbsp;<em>CP</em>&nbsp;groups was detected. However, no statistically significant difference (p&gt;0.05) was observed between the groups in phylloquinone levels.&nbsp;</span><span lang=\"TR\">It is concluded that&nbsp;<em>CP</em>&nbsp;causes free radical damage by causing oxidative stress, and retinol, is more effective and more resistant in the antioxidant defense system compared to cholecalciferol and phylloquinone.</span></p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2024-JAPS-2589"
}]