[{
  "type": "article-journal",
  "title": "Anti-oxidant, Anti-bacterial, and Anti-inflammatory activity of Scutellaria baicalensis Root Supercritical Fluid Extracts",
  "author": [
    {
      "family": "Park",
      "given": ""
    },
    {
      "family": "Lee",
      "given": ""
    }
  ],
  "issued": {
    "date-parts": [[2024]]
  },
  "container-title": "Journal of Animal and Plant Sciences",
  "ISSN": "1018-7081",
  "volume": "34",
  "issue": "6",
  "page": "1410-1423",
  "DOI": "https://doi.org/10.36899/JAPS.2024.6.0820",
  "abstract": "<p><em>Scutellaria baicalensis</em>&nbsp;(<em>S. baicalensis</em>) root extract has been used for a long time in Oriental medicine and the cosmetics industry due to its natural anti-oxidant properties in disease treatment. However, comprehensive studies comparing the physiological activities of different&nbsp;<em>S. baicalensis</em>&nbsp;root extracts are lacking. Specifically, there is a need to compare&nbsp;<em>S. baicalensis</em>&nbsp;root hydrothermal extract (SBHE),&nbsp;<em>S. baicalensis</em>&nbsp;root 75% ethyl alcohol extract (SBAE), and&nbsp;<em>S. baicalensis</em>&nbsp;root supercritical fluid extracts (SBSEs) simultaneously. In this study, we extracted&nbsp;<em>S. baicalensis</em>&nbsp;roots using three different methods: hydrothermal, 75% ethyl alcohol, and supercritical fluid extraction. We then evaluated their radical scavenging activities, SOD-like activity, anti-bacterial activities, and the production of inflammatory factors. Among the extracts tested, the&nbsp;<em>S. baicalensis</em>&nbsp;root supercritical fluid 35&deg;C extract (SBSE35) exhibited superior overall physiological activities. Notably, only the SBSEs demonstrated anti-bacterial activity against&nbsp;<em>Staphylococcus aureus</em>, whereas SBHE and SBAE did not. SBHE and SBAE increased interleukin (IL)-6 levels (p &le; 0.05). Additionally, SBHE and SBAE showed a slight decrease in IL-8 at low concentrations, but an increase in IL-8 production in a concentration-dependent manner. In contrast, SBSE35 significantly reduced both IL-6 and IL-8 levels (p &le; 0.05). These findings suggest that SBSE35 has greater potential for improving human health in the cosmetics and pharmaceutical fields.</p>",
  "publisher": "Pakistan Agricultural Scientists Forum",
  "URL": "https://thejaps.org.pk/AbstractView.aspx?mid=2023-JAPS-1438"
}]